Indian court to rule on generic drug industry

NEW DELHI (AP) — From Africa's crowded AIDS clinics to the malarial jungles of Southeast Asia, the lives of millions of ill people in the developing world are hanging in the balance ahead of a legal ruling that will determine whether India's drug companies can continue to provide cheap versions of many life-saving medicines.

The case — involving Swiss drug maker Novartis AG's cancer drug Glivec — pits aid groups that argue India plays a vital role as the pharmacy to the poor against drug companies that insist they need strong patents to make drug development profitable. A ruling by India's Supreme Court is expected in early 2013.

"The implications of this case reach far beyond India, and far beyond this particular cancer drug," said Leena Menghaney, from the aid group Doctors Without Borders. "Across the world, there is a heavy dependence on India to supply affordable versions of expensive patented medicines."

With no costs for developing new drugs or conducting expensive trials, India's $26 billion generics industry is able to sell medicine for as little as one-tenth the price of the companies that developed them, making India the second-largest source of medicines distributed by UNICEF in its global programs.

Indian pharmaceutical companies such as Cipla, Cadila Laboratories and Lupin have emerged over the past decade as major sources of generic cancer, malaria, tuberculosis and AIDS drugs for poor countries that can't afford to pay Western prices.

The 6-year-old case that just wrapped up in the Supreme Court revolves around a legal provision in India's 2005 patent law that is aimed at preventing companies from getting fresh patents for making only minor changes to existing medicines — a practice known as "evergreening."

Novartis' argued that a new version of Glivec — marketed in the U.S. as Gleevec — was a significant change from the earlier version because it was more easily absorbed by the body.

India's Patent Controller turned down the application, saying the change was an obvious development, and the new medicine was not sufficiently distinct from the earlier version to warrant a patent extension.

Patient advocacy groups hailed the decision as a blow to "evergreening."

But Western companies argued that India's generic manufacturers were cutting the incentive for major drug makers to invest in research and innovation if they were not going to be able to reap the exclusive profits that patents bring.

"This case is about safeguarding incentives for better medicines so that patients' needs will be met in the future," says Eric Althoff, a Novartis spokesman.

International drug companies have accused India of disregarding intellectual property rights, and have pushed for stronger patent protection that would weaken India's generics industry.

Earlier this year, an Indian manufacturer was allowed to produce a far cheaper version of the kidney and liver cancer treatment sorefinib, manufactured by Bayer Corp.

Bayer was selling the drug for about $5,600 a month. Natco, the Indian company, said its generic version would cost $175 a month, less than 1/30th as much. Natco was ordered to pay 6 percent in royalties to Bayer.

Novartis says the outcome of the new case will not affect the availability of generic versions of Glivec because it is covered by a grandfather clause in India's patent law. Only the more easily absorbed drug would be affected, Althoff said, adding that its own generic business, Sandoz, produces cheap versions of its drugs for millions across the globe.

Public health activists say the question goes beyond Glivec to whether drug companies should get special protection for minor tweaks to medicines that others could easily have uncovered.

"We're looking to the Supreme Court to tell Novartis it won't open the floodgates and allow abusive patenting practices," said Eldred Tellis, of the Sankalp Rehabilitation Centre, a private group working with HIV patients.

The court's decision is expected to be a landmark that will influence future drug accessibility and price across the developing world.

"We're already paying very high prices for some of the new drugs that are patented in India," said Petros Isaakidis, an epidemiologist with Doctors Without Borders. "If Novartis' wins, even older medicines could be subject to patenting again, and it will become much more difficult for us in future to provide medicines to our patients being treated for HIV, hepatitis and drug resistant TB."

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Chelsea Clinton Raises Profile During Mom's Illness

While Hillary Clinton was in the hospital it was daughter Chelsea -- not the secretary of state or the former president Bill Clinton -- who spoke for the family.

She, along with the State Department, doled out what little information the family wanted to share in a series of tweets and when her mother was released from the hospital, it was Chelsea who delivered the thanks on behalf of her parents, tweeting her gratitude to the doctors as well as those who kept her mother in their thoughts while she recovered from a blood clot.

When Hillary Clinton leaves office, possibly at the end of this month, it will be the first time since 1982 that a Clinton will not be holding a public office.

The watch will be on whether Hillary Clinton makes another run for the White House in 2016, but almost inevitably people will also be watching to see if Chelsea Clinton decides to run for office, too.

"Americans always look for dynasties: Bush, Kennedy, Cuomo, Clinton … it's some kind of continuity. There will always be pressure on her to run for public office," said Hank Sheinkopf, a Democratic political strategist in New York.

"She's learning from the two best politicians in recent American history and she understands when to hold them and when to fold them," Sheinkopf said.

That sense of dynasty could also present a significant hurdle.

James Devaney/Getty Images

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"She's got to A, demonstrate that she has the charisma of her father, or B, demonstrate that she has the policy chops of her mother. And I think like most people she is somewhere in between," a former Hillary Clinton aide from her 2008 campaign said. "People are judging her through each of her parents and it's an impossible standard."

Chelsea Clinton, 32, has inched towards a possible political career in recent statements and has become more politically active.

In an interview with Vogue published in August she was more open to it than she has been in the past, telling the magazine, "Before my mom's (presidential) campaign I would have said no," but "now I don't know."

"I believe that engaging in the political process is part of being a good person. And I certainly believe that part of helping to build a better world is ensuring that we have political leaders who are committed to that premise. So if there were to be a point where it was something I felt called to do and I didn't think there was someone who was sufficiently committed to building a healthier, more just, more equitable, more productive world? Then that would be a question I'd have to ask and answer."

Clinton also spoke of a change in her private to public life:

"Historically I deliberately tried to lead a private life in the public eye," she told the magazine. "And now I am trying to lead a purposefully public life."

Besides her work as a special correspondent with NBC, Chelsea Clinton has taken on high profile roles with her father's Clinton Global Initiative. She sits on several corporate boards and has both moderated and sat on panels discussing both women in politics and childhood obesity, among other issues.

She has also worked toward making same-sex marriage legal in New York last year, as well as gay marriage referendums in Maine, Maryland, Wisconsin and Washington state, all of which were successful in November. She has also been active in superstorm Sandy recovery, most notably delivering aid to the devastated Rockaways with her father.

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Lebanon asks for $180 million to aid Syrian refugees

BEIRUT (Reuters) - Lebanon, now a haven for 170,000 Syrians fleeing civil war, has asked foreign donors for $180 million to help care for them and said it will register and recognize refugees after a year-long hiatus.

The Beirut government has officially sought to "dissociate" itself from the 21-month-old struggle in Syria, nervous about the destabilizing impact of the increasingly sectarian conflict in its bigger neighbor on its own delicate communal balance.

But there has been pressure from humanitarian agencies and the public to do more to help Syrian refugees in Lebanon.

The cabinet, which approved the measures after a six-hour session on Thursday night, rejected a proposal by Energy Minister Gebran Bassil, a Christian, to close the border to stop the influx into Lebanon, where mainly Sunni Muslim Syrian refugees now account for almost 5 percent of the population.

Bassil belongs to the Free Patriotic Movement, part of a political alliance with Shi'ite Muslim militant group Hezbollah, which supports Syrian President Bashar al-Assad.

However, Hezbollah leader Hassan Nasrallah said in a speech on Thursday that the border should stay open for refugees.

Social Affairs Minister Wael Abu Faour told reporters after the cabinet debate: "The Lebanese state will register the refugees...and guarantee aid and protection for the actual refugees in Lebanon."

Until now Syrian refugees have found shelter with local communities in Lebanon, rather than being housed in camps, as in the other two main host countries, Jordan and Turkey. Abu Faour did not say if camps would now be constructed.

"FIRST CONCRETE PLAN"

Lebanon's ambivalent attitude to the new arrivals is partly a legacy of its own 15-year civil war, a conflict fuelled by sectarian tensions which linger on, especially over the presence of 400,000 Sunni Palestinian refugees in the country.

Ninette Kelley, representative of the U.N. refugee agency (UNHCR) in Lebanon, said the government's action was "the first concrete plan" it had presented to the international community.

She said Lebanon had previously given formal recognition to Syrian refugees who entered via official border points, but not to those who had crossed illegally, either because they feared authorities or to escape violence near their homes.

This group accounts for around 30 percent of all Syrian refugees in Lebanon and the government's decision should allow them to register for legal refugee status, Kelley said.

"Initially the government jointly registered Syrian refugees with UNHCR through its High Relief Commission. It stopped in 2011 as the numbers became larger due to insufficient capacity," she said, adding that joint registration would now resume.

The United Nations says more than 560,000 Syrians have fled abroad. In Lebanon, many not hosted by friends or relations live in shacks of wood and plastic sheeting. In the southern city of Tyre, they brave the winter cold and wash in the sea.

Lebanese politics is marred by sectarian divisions that have been inflamed by the mainly Sunni revolt against Assad, whose minority Alawite sect is derived from Shi'ite Islam.

Syria-related violence has flared periodically in the northern port of Tripoli, which has a Sunni majority and an Alawite minority, as well as in Beirut and Sidon in the south.

Assad's Lebanese opponents blame Syria, which stationed troops in Lebanon from 1976 to 2005, for the unresolved killing of Lebanese security official Wissam al-Hassan in October.

Hassan had been leading an investigation that implicated Damascus and Hezbollah in the 2005 assassination of former Lebanese prime minister Rafik al-Hariri, a Sunni.

(Reporting by Issam Abdallah, Oliver Holmes and Ayat Basma; Editing by Alistair Lyon)

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France seeks to grill Swiss shooter over Britons' murders in Alps

GENEVA: French police investigating the murder of a British-Iraqi family in the Alps have asked to question a Swiss gunman who killed three women in his home village, police in Switzerland said Friday.

The police in the neighbouring French region of Haute-Savoie made the request to their colleagues in the Swiss canton of Valais, where on Thursday the gunman went on a shooting spree, a spokesman told AFP.

Saad al-Hilli, his wife Iqbal and her mother Suhaila al-Allaf, were all found dead inside their estate car near Lake Annecy in Haute-Savoie on September 5, along with a French cyclist who police believe was an innocent bystander.

On Thursday, a gunman with psychiatric and drug problems killed three women and wounded two men in a shooting spree in the tiny Swiss village where he lived.

-AFP/fl

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Over 700,000 children in Himachal to get polio drops

SHIMLA: Over 700,000 children will be administered polio drops in a two-round campaign beginning this month in Himachal Pradesh, an official said here Friday.

More than 5,850 booths, each catering to a population of 125, would be set up for the pulse polio immunization campaign to be carried out Jan 20 and Feb 24, Principal Secretary, Health and Family Welfare, Ali R. Rizvi said in a statement.

He said residents of even snow-bound areas would be covered.

Special booths would be set up in forest and remote areas too for the children of Gaddi and Gujjar tribes, Rizvi added.

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Flu? Malaria? Disease forecasters look to the sky

NEW YORK (AP) — Only a 10 percent chance of showers today, but a 70 percent chance of flu next month.

That's the kind of forecasting health scientists are trying to move toward, as they increasingly include weather data in their attempts to predict disease outbreaks.

In one recent study, two scientists reported they could predict — more than seven weeks in advance — when flu season was going to peak in New York City. Theirs was just the latest in a growing wave of computer models that factor in rainfall, temperature or other weather conditions to forecast disease.

Health officials are excited by this kind of work and the idea that it could be used to fine-tune vaccination campaigns or other disease prevention efforts.

At the same time, experts note that outbreaks are influenced as much, or more, by human behavior and other factors as by the weather. Some argue weather-based outbreak predictions still have a long way to go. And when government health officials warned in early December that flu season seemed to be off to an early start, they said there was no evidence it was driven by the weather.

This disease-forecasting concept is not new: Scientists have been working on mathematical models to predict outbreaks for decades and have long factored in the weather. They have known, for example, that temperature and rainfall affect the breeding of mosquitoes that carry malaria, West Nile virus and other dangerous diseases.

Recent improvements in weather-tracking have helped, including satellite technology and more sophisticated computer data processing.

As a result, "in the last five years or so, there's been quite an improvement and acceleration" in weather-focused disease modeling, said Ira Longini, a University of Florida biostatistician who's worked on outbreak prediction projects.

Some models have been labeled successes.

In the United States, researchers at Johns Hopkins University and the University of New Mexico tried to predict outbreaks of hantavirus in the late 1990s. They used rain and snow data and other information to study patterns of plant growth that attract rodents. People catch the disease from the droppings of infected rodents.

"We predicted what would happen later that year," said Gregory Glass, a Johns Hopkins researcher who worked on the project.

More recently, in east Africa, satellites have been used to predict rainfall by measuring sea-surface temperatures and cloud density. That's been used to generate "risk maps" for Rift Valley fever — a virus that spreads from animals to people and in severe cases can cause blindness or death. Researchers have said the system in some cases has given two to six weeks advance warning.

Last year, other researchers using satellite data in east Africa said they found that a small change in average temperature was a warning sign cholera cases would double within four months.

"We are getting very close to developing a viable forecasting system" against cholera that can help health officials in African countries ramp up emergency vaccinations and other efforts, said a statement by one of the authors, Rita Reyburn of the International Vaccine Institute in Seoul, South Korea.

Some diseases are hard to forecast, such as West Nile virus. Last year, the U.S. suffered one of its worst years since the virus arrived in 1999. There were more than 2,600 serious illnesses and nearly 240 deaths.

Officials said the mild winter, early spring and very hot summer helped spur mosquito breeding and the spread of the virus. But the danger wasn't spread uniformly. In Texas, the Dallas area was particularly hard-hit, while other places, including some with similar weather patterns and the same type of mosquitoes, were not as affected.

"Why Dallas, and not areas with similar ecological conditions? We don't really know," said Roger Nasci of the Centers for Disease Control and Prevention. He is chief of the CDC branch that tracks insect-borne viruses.

Some think flu lends itself to outbreak forecasting — there's already a predictability to the annual winter flu season. But that's been tricky, too.

Seasonal flu reports come from doctors' offices, but those show the disease when it's already spreading. Some researchers have studied tweets on Twitter and searches on Google, but their work has offered a jump of only a week or two on traditional methods.

In the study of New York City flu cases published last month in the Proceedings of the National Academy of Sciences, the authors said they could forecast, by up to seven weeks, the peak of flu season.

They designed a model based on weather and flu data from past years, 2003-09. In part, their design was based on earlier studies that found flu virus spreads better when the air is dry and turns colder. They made calculations based on humidity readings and on Google Flu Trends, which tracks how many people are searching each day for information on flu-related topics (often because they're beginning to feel ill).

Using that model, they hope to try real-time predictions as early as next year, said Jeffrey Shaman of Columbia University, who led the work.

"It's certainly exciting," said Lyn Finelli, the CDC's flu surveillance chief. She said the CDC supports Shaman's work, but agency officials are eager to see follow-up studies showing the model can predict flu trends in places different from New York, like Miami.

Despite the optimism by some, Dr. Edward Ryan, a Harvard University professor of immunology and infectious diseases, is cautious about weather-based prediction models. "I'm not sure any of them are ready for prime time," he said.

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Senate Swears in Historic 20th Female Senator

Today the Senate will make history, swearing in a record-breaking 20 female senators – 4 Republicans and 16 Democrats – in office.

As the 113th Congress is sworn in today on Capitol Hill, ABC "World News" anchor Diane Sawyer has an exclusive joint interview with the historic class of female Senators.

Diane Sawyer's complete interview will air on World News this evening.

"I can't tell you the joy that I feel in my heart to look at these 20 gifted and talented women from two different parties, different zip codes to fill this room," Sen. Barbara Mikulksi, D-Md., said while surrounded by the group of women senators. "In all of American history only 16 women had served. Now there are 20 of us."

Senator-elect Deb Fischer, R-Neb., becomes today the first women to be elected as a senator in Nebraska.

"It was an historic election," Fischer said, "But what was really fun about it were the number of mothers and fathers who brought their daughters up to me during the campaign and said, "Can we get a picture? Can we get a picture?' Because people realize it and -- things do change, things do change."

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The women senators all agree that women will be getting things done in this new Congress, a sign of optimism felt for the new Congress, after the bruising battles of the 112th Congress.

"We're in force and we're in leadership positions, but it's not just the position that we hold. I can tell you this is a can-do crowd," Mikulski said of both Democrats and Republican senators in the room. "We are today ready to be a force in American politics."

And while the number of women in the Senate today makes historic, many of the women agreed that they want to keep fighting to boost those numbers. Sen. Barbara Boxer, D-Calif., said that women are still "underrepresented" in the Senate.

"I think that until we get to 50, we still have to fight because it's still a problem," Boxer said. "I think this class as you look around, Republicans and Democrats... I think that because of this new class and the caliber of the people coming and the quality of the people coming, I think that hopefully in my lifetime -- and I really do hope and pray this is the case -- we will see 50 percent. "

No Sorority Here, Even With the Will to Work Together

The cooperation does not make them a "sorority," Sen. Dianne Feinstein, D-Calif., says. There are real differences in ideology and personality and they don't want their gender to define them as senators.

But the women also admit that they believe having more women in the room would help in fierce negotiations, compromise, and legislating on Capitol Hill, traits they say do not come as naturally to their male colleagues in the Senate. That sentiment enjoys bipartisan support among the women of the Senate.

"What I find is with all due deference to our male colleagues, that women's styles tend to be more collaborative," Sen. Susan Collins, R-Maine, said.

Sen. Claire McCaskill, D-Mo., said by nature women are "less confrontational." Sen-elect Mazie Hirono, D-Hawaii, says that women are "problem solvers."

Sen. Amy Klobuchar, D-Minn., says that women have a camaraderie which helps in relationships that are key to negotiations on Capitol Hill, something she says comes natural to women more than men.

"I think there's just a lot of collaboration between the women senators and... advice and really standing up for each other that you don't always see with the men," she said.

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Myanmar says jets used against Kachin rebels

YANGON (Reuters) - Myanmar's military has used jets to attacks rebel fighters in northern Kachin state, the government said on Thursday, its first admission of an intensification of a conflict that has raised doubts about its reformist credentials.

Rebel sources have reported aerial bombings, shelling and even the use of chemical weapons since December 28 after the Kachin Independence Army (KIA) ignored an ultimatum to stop blocking an army supply route in the hilly, resource-rich state where more than 50,000 people have been displaced.

Official newspapers said that air support was used on December 30 to thwart KIA fighters who had occupied a hill and were attacking logistics units of the Tatmadaw, as Myanmar's military is known.

"The Tatmadaw troops cleared Point-771 hill and its surrounding areas where the KIA troops were attacking the Tatmadaw logistic troops," the New Light of Myanmar, a government mouthpiece, said. "The air cover was used in the attack."

U.N. Secretary-General Ban Ki-moon voiced concern on Wednesday over reports of helicopters and fighter jets being used in the state bordering China. The KIA said the attacks were intended to clear the path for an assault on its headquarters in Laisa.

Ban called on Myanmar's government to "desist from any action that could endanger the lives of civilians" and reiterated demands for humanitarian aid groups to be granted access, U.N. spokesman Martin Nesirky said in a statement.

President Thein Sein's quasi-civilian administration insists it wants a ceasefire and political dialogue. It says troops have acted only in self-defense and on Thursday denied having plans to seize the KIA's stronghold.

DOMINANT MILITARY

The escalation of fighting has raised doubts about the sincerity of the reformist ex-generals running the government and the extent of their power in a country the size of Britain and France plagued by decades of internal conflict.

Some analysts and diplomats say central government is either not fully committed to peace with the KIA or unable to assert control over the military, which still dominates politics and the economy despite formally ceding power in March 2011.

Colonel James Lum Dau, a Thai-based spokesman for the KIA's political wing, said Kachin officials on the ground had reported up to 300 people killed in air strikes.

"We are in a defensive position. Right now more people are suffering not only bombings, but shelling and spraying of chemical weapons with helicopter gunships and jets," he said. "Only god knows what to do. We are praying."

It is difficult for journalists to independently verify accounts from the two sides.

Fighting erupted in Kachin in June 2010, ending a 17-year truce, and has continued even as government negotiators have agreed ceasefires elsewhere with ethnic Shan, Chin, Mon and Karen militias after decades of fighting in border areas.

Mistrust runs deep between the military and the KIA, which was once backed by China, and multiple rounds of talks aimed at reaching a ceasefire have gone nowhere. Analysts say a history of bad blood and a battle for control of resources, including highly lucrative jade, could be stoking the unrest.

Zaw Htay, a senior official in Thein Sein's office, told Reuters no air strikes had taken place but K-8 trainer jets had provided cover fire to protect ground troops from rebel attacks. The military, he said, had no intention of seizing the KIA's headquarters.

"The president has said this and at the same time he has invited KIA leaders to come and talk with him in Naypyitaw, but they still haven't responded," Zaw Htay said.

(Additional reporting by Paul Carsten in Bangkok; Writing by Martin Petty; Editing by Alan Raybould)

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141 journalists killed in 2012: media watchdog

GENEVA: Last year was one of the deadliest on record for journalists, with 141 killed in 29 different countries and Syria the most dangerous place on earth for reporters, a media watchdog said Thursday.

The Swiss-based Press Emblem Campaign (PEC), which fights for the protection of journalists, said the figure was up by 31 percent on 2011.

At least 37 journalists, among them 13 working for foreign media, were killed in Syria, it said in a statement.

Four journalists are reported missing or detained: Ukrainian Anhar Kochneva, Jordanian-Palestinian Bashar Fahmi, freelance US reporter Austin Tice and another American reporter James Foley, who has contributed video to Agence France-Presse.

The situation in Somalia has deteriorated dramatically, where 19 were killed, said the PEC.

Three Latin American countries followed among the most dangerous places: Mexico with 11 journalists killed, Brazil also with 11 dead, and Honduras, where six journalists were killed.

The Philippines ranked number seven with six killed, followed by Bangladesh and India with four each, said the PEC.

The New York-based Committee to Protect Journalists for its part said last month that 67 reporters were killed in 2012, up 42 percent from the previous year, due in large part to the Syria conflict, shootings in Somalia, violence in Pakistan and killings of reporters in Brazil.

The Paris-based press rights group Reporters without Borders (RSF) meanwhile put the number of those killed at 88 last year.

-AFP/fl

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PM unveils new science policy

KOLKATA: India today unveiled a new science policy that lays greater thrust on innovation, establishing research institutes and encourage women scientists with an aim to position itself among the top five scientific powers in the world by 2020.

The Science, Technology and Innovation (STI) Policy, 2013 also speaks of modifying the intellectual property regime to provide for marching rights for social good when supported by public funds and co-sharing of patents generated in the public private partnership mode.

Unveiling the STI policy, Prime Minister Manmohan Singh said it aspires to position India among the top five global scientific powers by 2020.

"It is an ambitious goal," he said, adding the policy also aims at producing and nurturing talent in science, to stimulate research in universities, to develop young leaders in the field of science and to reward performance.

It also seeks to create a policy environment for greater private sector participation in research and innovation and to forge international alliances and collaborations to meet the national agenda, he said.

The policy also talks of raising gross expenditure in R&D to two per cent of GDP from the current one per cent in this decade by encouraging enhanced private sector contribution.

"The policy is truly aspirational and seeks to accelerate the pace of discovery and delivery of science-led solutions for faster, sustainable and inclusive growth," Science and Technology Minister S Jaipal Reddy said.

He dubbed the policy as a "rare and resounding expression of collective will and wisdom of the Indian scientific community that is at once a product of and a clarion call of the scientific community".

The document is a revision of the 2003 policy which sought to bring science and technology together and emphasised on the need for higher investment into R&D to address national problems.

The (STI) policy also seeks to trigger an ecosystem for innovative abilities to flourish by leveraging partnerships among diverse stakeholders and by encouraging and facilitating enterprises to invest in innovations.

The aim of the policy is to accelerate the pace of discovery, diffusion and delivery of science-led solutions for serving the aspirational goals of India for faster, sustainable and inclusive growth.

The key features of the STI Policy 2013 include making careers in science, research and innovation attractive, establishing world-class infrastructure for R&D for gaining global leadership in some select frontier areas of science.

The policy also includes linking contributions of science, research and innovation system with the inclusive economic growth agenda and combining priorities of excellence and relevance.

It also stresses on creating an environment for enhanced private sector participation in R&D, enabling conversion of R&D outputs into societal and commercial applications by replicating successful models as well as establishing of new public-private partnership structures.

India first unveiled its Scientific Policy Resolution in 1958 which resolved to "foster, promote and sustain" the cultivation of science and scientific research in all its aspects.

The Technology Policy Statement of 1983 focused on the need to attain technological competence and self reliance.

Officials said in today's world, innovation was no longer a mere appendage to S&T but has assumed centre stage in its own right in the development of countries around the world.

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